- |||||||||| Ibrance (palbociclib) / Pfizer, Kisqali (ribociclib) / Novartis, Verzenio (abemaciclib) / Eli Lilly
Retrospective data, Review, Journal, Adverse events: Hematological toxicity of cyclin-dependent kinase 4/6 inhibitors in patients with breast cancer: a network meta-analysis and pharmacovigilance study. (Pubmed Central) - Feb 1, 2025 Signals indicating occurrence of leukopenia, neutropenia, anemia, and thrombocytopenia were identified for three CDK4/6 inhibitors. Abemaciclib, palbociclib, and ribociclib showed significant but inconsistent hematological toxicity risks.
- |||||||||| Cabometyx (cabozantinib tablet) / Exelixis
Journal, Metastases: A case of complete remission by cabozantinib as an end-line treatment for advanced hepatocellular carcinoma. (Pubmed Central) - Jan 31, 2025 A 71-year-old man presented to our hospital for treatment of HCC with chronic hepatitis C. He was refractory to sorafenib, lenvatinib, regorafenib, and ramucirumab and started atezolizumab and bevacizumab therapy in November 2020...The patient did not show disease progression for 11 months without receiving any treatment for HCC. To the best of our knowledge, this is the first report of CR with cabozantinib in advanced HCC.
- |||||||||| Prolia (denosumab) / Amgen
Review, Journal: Proceedings of the 2024 Santa Fe Bone Symposium: Update on the Management of Osteoporosis and Rare Bone Diseases. (Pubmed Central) - Jan 30, 2025 Topics included an update on clinical uses of osteoanabolic agents, management of patients discontinuing denosumab, bone health optimization for orthopedic surgery, estrogen and testosterone in the management of osteoporosis, osteoporosis treatment in the very old, overview of rare bone diseases, treat-to-target for osteoporosis, and a progress report on global activities of Bone Health ECHO...Ancillary events addressed modern approaches to menopause and bone health, case studies of management of patients at very high fracture risk, and management of patients with rare bone diseases, such as hypophosphatasia, fibrodysplasia ossificans progressiva, X-linked hypophosphatemia, and hypoparathyroidism. These proceedings of the SFBS present the clinical highlights of the plenary sessions and the discussions that followed.
- |||||||||| Tezspire (tezepelumab-ekko) / AstraZeneca, Amgen
Journal: Effect of Tezepelumab on Sino-Nasal Outcome Test (SNOT)-22 Domain and Symptom-Specific Scores in Patients with Severe, Uncontrolled Asthma and a History of Chronic Rhinosinusitis with Nasal Polyps. (Pubmed Central) - Jan 30, 2025 P3 Method validation was performed according to the International Council for Harmonization guidelines and the analysis of ivabradine, its process related impurities (dehydro ivabradine, acetyl ivabradine, and hydroxy ivabradine) and a major oxidative degradation product (ivabradine N-oxide) was successfully performed by this method. In patients with severe, uncontrolled asthma and a history of CRSwNP, tezepelumab improved rhinosinusitis symptoms across multiple domains, as well as asthma exacerbations, lung function, asthma control, and health-related quality of life.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / AbbVie
Journal: Disease activity-guided dose optimisation including discontinuation of TNF-inhibitors in rheumatoid arthritis is effective for up to 10 years: an observational follow-up of the DRESS study. (Pubmed Central) - Jan 30, 2025 In patients with severe, uncontrolled asthma and a history of CRSwNP, tezepelumab improved rhinosinusitis symptoms across multiple domains, as well as asthma exacerbations, lung function, asthma control, and health-related quality of life. Long-term disease activity-guided dose optimization of TNF inhibitors in RA, including discontinuation and multiple tapering attempts, remains safe and effective.
- |||||||||| Journal: Costimulation blockade: the next generation. (Pubmed Central) - Jan 30, 2025
Investigational agents with subcutaneous delivery methods could overcome logistical challenges, improve adherence, and redefine posttransplant care. These advancements in costimulation blockade may enhance long-term graft survival and transform the management of KT recipients.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen
Journal: Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency. (Pubmed Central) - Jan 30, 2025 Her condition improved after treatment with etanercept...Fever and hemiplegia were the main manifestations in this patient, without typical rashes. DADA2 was finally confirmed by enzymology and genetic testing, and we believe this is the first reported case of the c.1082-7T>A intronic variant in DADA2, and the RNA studies conducted in this case have been pivotal in assessing its pathogenicity.
- |||||||||| Prolia (denosumab) / Amgen
Journal: Impact of glucocorticoids on the therapeutic efficacy of denosumab against osteoporosis in patients with rheumatoid arthritis. (Pubmed Central) - Jan 30, 2025 Similarly, in patients with anti-cyclic citrullinated peptide (CCP) antibody positivity or those treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (DMARDs), although there were significant increases in the T-score and areal BMD at all sites in both groups, there were no significant between-group differences. Our findings suggest that the GC dose considered to increase the risk of GIOP did not significantly attenuate the therapeutic efficacy of denosumab in RA patients, including those positive for anti-CCP antibodies and users of biologic or targeted synthetic DMARDs.
- |||||||||| astegolimab (RG 6149) / Amgen, Roche
Trial completion, Trial completion date, Trial primary completion date: A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects (clinicaltrials.gov) - Jan 30, 2025 P1, N=78, Completed, Our findings suggest that the GC dose considered to increase the risk of GIOP did not significantly attenuate the therapeutic efficacy of denosumab in RA patients, including those positive for anti-CCP antibodies and users of biologic or targeted synthetic DMARDs. Active, not recruiting --> Completed | Trial completion date: Apr 2025 --> Oct 2024 | Trial primary completion date: Apr 2025 --> Oct 2024
- |||||||||| Stivarga (regorafenib) / Bayer
P3 data, Journal, Metastases: INTEGRATE IIa Phase III Study: Regorafenib for Refractory Advanced Gastric Cancer. (Pubmed Central) - Jan 29, 2025 This study unveils the critical role of NSRP1 in regulating the IFN signaling pathway and the CDK4/6i resistance, which could be a promising biomarker for predicting therapy response. Regorafenib improves survival compared with placebo in refractory AGOC.
- |||||||||| Praluent (alirocumab) / Sanofi, Regeneron, ezetimibe / Generic mfg., Repatha (evolocumab) / Amgen, Astellas
Retrospective data, Journal: Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on (Pubmed Central) - Jan 29, 2025 No abstract available Subgroup analyses revealed consistent treatment effect amongst comparators vs placebo:
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen, Keytruda (pembrolizumab) / Merck (MSD)
Trial completion date, Trial primary completion date: Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Jan 29, 2025 P1/2, N=36, Recruiting, Here, the authors describe the timing, occurrence, and duration of these adverse events and review the management and risk-mitigation strategies used by clinical investigators during the DeLLphi-301 trial. Trial completion date: Oct 2024 --> Oct 2025 | Trial primary completion date: Oct 2024 --> Oct 2025
- |||||||||| Tyvyt (sintilimab) / Eli Lilly, Fruzaqla (fruquintinib) / Takeda, Stivarga (regorafenib) / Bayer
Enrollment change: Sintilimab Combined with Fruquintinib/Regorafenib (clinicaltrials.gov) - Jan 29, 2025 P2, N=57, Recruiting, Trial completion date: Dec 2024 --> Mar 2026 | Trial primary completion date: Dec 2024 --> Mar 2026 N=141 --> 57
- |||||||||| Ibrance (palbociclib) / Pfizer, fulvestrant / Generic mfg., Itovebi (inavolisib) / Roche
Review, Journal: Inavolisib: First Approval. (Pubmed Central) - Jan 28, 2025 In the EU and other countries worldwide, regulatory review of inavolisib is currently underway. This article summarises the milestones in the development of inavolisib leading to this first approval for endocrine-resistant, PIK3CA-mutated, HR-positive, HER2-negative, locally advanced or metastatic breast cancer.
- |||||||||| Tepezza (teprotumumab-trbw) / Roche, Amgen, Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: Novel perspectives on the pharmacological treatment of thyroid-associated ophthalmopathy. (Pubmed Central) - Jan 28, 2025 In addition, some drug candidates and molecular targets identified in the TAO in vitro model have shown promising prospects. This article briefly reviews the potential new strategies for future clinical treatment and the progress of new drug therapies for TAO.
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