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  • ||||||||||  Repatha (evolocumab) / Amgen, Astellas
    Journal:  Evolocumab Achieves Low LDL Cholesterol Without Long-Term Cognitive Risks. (Pubmed Central) -  Jan 31, 2025   
    Despite evidence-based treatment preferences supported by clinical experience, factors other than scientific evidence influence decision making, particularly with medications. No abstract available
  • ||||||||||  Cabometyx (cabozantinib tablet) / Exelixis
    Journal, Metastases:  A case of complete remission by cabozantinib as an end-line treatment for advanced hepatocellular carcinoma. (Pubmed Central) -  Jan 31, 2025   
    A 71-year-old man presented to our hospital for treatment of HCC with chronic hepatitis C. He was refractory to sorafenib, lenvatinib, regorafenib, and ramucirumab and started atezolizumab and bevacizumab therapy in November 2020...The patient did not show disease progression for 11 months without receiving any treatment for HCC. To the best of our knowledge, this is the first report of CR with cabozantinib in advanced HCC.
  • ||||||||||  Prolia (denosumab) / Amgen
    Review, Journal:  Proceedings of the 2024 Santa Fe Bone Symposium: Update on the Management of Osteoporosis and Rare Bone Diseases. (Pubmed Central) -  Jan 30, 2025   
    Topics included an update on clinical uses of osteoanabolic agents, management of patients discontinuing denosumab, bone health optimization for orthopedic surgery, estrogen and testosterone in the management of osteoporosis, osteoporosis treatment in the very old, overview of rare bone diseases, treat-to-target for osteoporosis, and a progress report on global activities of Bone Health ECHO...Ancillary events addressed modern approaches to menopause and bone health, case studies of management of patients at very high fracture risk, and management of patients with rare bone diseases, such as hypophosphatasia, fibrodysplasia ossificans progressiva, X-linked hypophosphatemia, and hypoparathyroidism. These proceedings of the SFBS present the clinical highlights of the plenary sessions and the discussions that followed.
  • ||||||||||  Journal:  Costimulation blockade: the next generation. (Pubmed Central) -  Jan 30, 2025   
    Investigational agents with subcutaneous delivery methods could overcome logistical challenges, improve adherence, and redefine posttransplant care. These advancements in costimulation blockade may enhance long-term graft survival and transform the management of KT recipients.
  • ||||||||||  Enbrel (etanercept) / Pfizer, Amgen
    Journal:  Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency. (Pubmed Central) -  Jan 30, 2025   
    Her condition improved after treatment with etanercept...Fever and hemiplegia were the main manifestations in this patient, without typical rashes. DADA2 was finally confirmed by enzymology and genetic testing, and we believe this is the first reported case of the c.1082-7T>A intronic variant in DADA2, and the RNA studies conducted in this case have been pivotal in assessing its pathogenicity.
  • ||||||||||  Prolia (denosumab) / Amgen
    Journal:  Impact of glucocorticoids on the therapeutic efficacy of denosumab against osteoporosis in patients with rheumatoid arthritis. (Pubmed Central) -  Jan 30, 2025   
    Similarly, in patients with anti-cyclic citrullinated peptide (CCP) antibody positivity or those treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (DMARDs), although there were significant increases in the T-score and areal BMD at all sites in both groups, there were no significant between-group differences. Our findings suggest that the GC dose considered to increase the risk of GIOP did not significantly attenuate the therapeutic efficacy of denosumab in RA patients, including those positive for anti-CCP antibodies and users of biologic or targeted synthetic DMARDs.
  • ||||||||||  astegolimab (RG 6149) / Amgen, Roche
    Trial completion, Trial completion date, Trial primary completion date:  A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects (clinicaltrials.gov) -  Jan 30, 2025   
    P1,  N=78, Completed, 
    Our findings suggest that the GC dose considered to increase the risk of GIOP did not significantly attenuate the therapeutic efficacy of denosumab in RA patients, including those positive for anti-CCP antibodies and users of biologic or targeted synthetic DMARDs. Active, not recruiting --> Completed | Trial completion date: Apr 2025 --> Oct 2024 | Trial primary completion date: Apr 2025 --> Oct 2024
  • ||||||||||  Stivarga (regorafenib) / Bayer
    P3 data, Journal, Metastases:  INTEGRATE IIa Phase III Study: Regorafenib for Refractory Advanced Gastric Cancer. (Pubmed Central) -  Jan 29, 2025   
    This study unveils the critical role of NSRP1 in regulating the IFN signaling pathway and the CDK4/6i resistance, which could be a promising biomarker for predicting therapy response. Regorafenib improves survival compared with placebo in refractory AGOC.
  • ||||||||||  Praluent (alirocumab) / Sanofi, Regeneron, ezetimibe / Generic mfg., Repatha (evolocumab) / Amgen, Astellas
    Retrospective data, Journal:  Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on (Pubmed Central) -  Jan 29, 2025   
    No abstract available Subgroup analyses revealed consistent treatment effect amongst comparators vs placebo:
  • ||||||||||  Blincyto (blinatumomab) / Astellas, Amgen, Keytruda (pembrolizumab) / Merck (MSD)
    Trial completion date, Trial primary completion date:  Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Jan 29, 2025   
    P1/2,  N=36, Recruiting, 
    Here, the authors describe the timing, occurrence, and duration of these adverse events and review the management and risk-mitigation strategies used by clinical investigators during the DeLLphi-301 trial. Trial completion date: Oct 2024 --> Oct 2025 | Trial primary completion date: Oct 2024 --> Oct 2025
  • ||||||||||  Tyvyt (sintilimab) / Eli Lilly, Fruzaqla (fruquintinib) / Takeda, Stivarga (regorafenib) / Bayer
    Enrollment change:  Sintilimab Combined with Fruquintinib/Regorafenib  (clinicaltrials.gov) -  Jan 29, 2025   
    P2,  N=57, Recruiting, 
    Trial completion date: Dec 2024 --> Mar 2026 | Trial primary completion date: Dec 2024 --> Mar 2026 N=141 --> 57
  • ||||||||||  Ibrance (palbociclib) / Pfizer, fulvestrant / Generic mfg., Itovebi (inavolisib) / Roche
    Review, Journal:  Inavolisib: First Approval. (Pubmed Central) -  Jan 28, 2025   
    In the EU and other countries worldwide, regulatory review of inavolisib is currently underway. This article summarises the milestones in the development of inavolisib leading to this first approval for endocrine-resistant, PIK3CA-mutated, HR-positive, HER2-negative, locally advanced or metastatic breast cancer.
  • ||||||||||  Tepezza (teprotumumab-trbw) / Roche, Amgen, Actemra IV (tocilizumab) / Roche, JW Pharma
    Review, Journal:  Novel perspectives on the pharmacological treatment of thyroid-associated ophthalmopathy. (Pubmed Central) -  Jan 28, 2025   
    In addition, some drug candidates and molecular targets identified in the TAO in vitro model have shown promising prospects. This article briefly reviews the potential new strategies for future clinical treatment and the progress of new drug therapies for TAO.