- |||||||||| Review, Journal: A Review of Clinical Trials of Cancer and Its Treatment as a Vaccine. (Pubmed Central) - Nov 13, 2023
Trial completion date: Dec 2023 --> Dec 2024 This brief discussion of vaccines and their varieties with examples also discusses vaccine clinical trials in relation to cancer diseases in this DNA and RNA-based cancer vaccine that has had successful clinical trials like the cervical cancer drug VGX-3100, the kidney cancer drug Pembrolizumab, MGN-1601, the prostate cancer drug pTVG-HP with rhGM-CSF, the melanoma cancer drug proteasome siRNA, and the lung cancer drug FRAME-001.
- |||||||||| INO-3107 / Inovio
P1/2 data, Journal: Interim Results of a Phase 1/2 Open-Label Study of INO-3107 for HPV-6 and/or HPV-11-Associated Recurrent Respiratory Papillomatosis. (Pubmed Central) - Oct 22, 2023 P1/2 This brief discussion of vaccines and their varieties with examples also discusses vaccine clinical trials in relation to cancer diseases in this DNA and RNA-based cancer vaccine that has had successful clinical trials like the cervical cancer drug VGX-3100, the kidney cancer drug Pembrolizumab, MGN-1601, the prostate cancer drug pTVG-HP with rhGM-CSF, the melanoma cancer drug proteasome siRNA, and the lung cancer drug FRAME-001. The data suggest that INO-3107 administered by IM/EP is tolerable and immunogenic and provides clinical benefit to adults with RRP.
- |||||||||| AZD8076 / AstraZeneca, Inovio, AZD5396 / Inovio, AstraZeneca
Enrollment open, Enrollment change, Trial completion date, Trial primary completion date: dMAbs for Prevention of COVID-19 (clinicaltrials.gov) - Sep 21, 2023 P1, N=39, Recruiting, Active, not recruiting --> Completed | Trial completion date: Jul 2023 --> Dec 2022 | Trial primary completion date: Jul 2023 --> Dec 2022 Active, not recruiting --> Recruiting | N=26 --> 39 | Trial completion date: Sep 2024 --> Sep 2025 | Trial primary completion date: Sep 2024 --> Sep 2025
- |||||||||| Covovax (NVX-CoV2373) / Novavax, Takeda, Serum Institute of India
Review, Journal: Vaccination is the most effective and best way to avoid the disease of COVID-19. (Pubmed Central) - Sep 3, 2023 Among the vaccines that stimulate the host's immune system with the help of DNA are: undergoing Phase 2/3 trials including INO-4800 (International Vaccine Institute; Inovio Pharmaceuticals), Symvivo, Canada-COVID19 (AnGes, Inc.); GX-19 (Genexine, Inc.). BNT162b2
- |||||||||| GNOS-PV02 / Geneos Therap
Enrollment closed, Trial completion date, Combination therapy, Metastases: GT-30: GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects With Advanced HCC (clinicaltrials.gov) - Jun 15, 2023 P1/2, N=36, Active, not recruiting, The low ORR among patients with cervical cancer led to study discontinuation despite a clinically meaningful disease control rate. Recruiting --> Active, not recruiting | Trial completion date: Aug 2023 --> Jun 2025
- |||||||||| INO-4500 / Inovio, EBS-Lassa / Emergent Biosolutions
Review, Journal: Lassa fever vaccine candidates: A scoping review of vaccine clinical trials. (Pubmed Central) - Jun 5, 2023 Trial completion date: May 2024 --> Sep 2029 | Trial primary completion date: May 2024 --> Sep 2029 Though LF vaccine development is still in early stages, current progress towards a safe and effective vaccine is encouraging.
- |||||||||| AZD8076 / AstraZeneca, Inovio, AZD5396 / Inovio, AstraZeneca
Enrollment closed, Trial completion date, Trial primary completion date: dMAbs for Prevention of COVID-19 (clinicaltrials.gov) - Apr 21, 2023 P1, N=26, Active, not recruiting, The findings showed that high doses of current MERS-CoV vaccine candidates conferred better immunogenicity than low doses and that there were no differences in the safety of the vaccines. Recruiting --> Active, not recruiting | Trial completion date: Nov 2023 --> Sep 2024 | Trial primary completion date: Nov 2023 --> Sep 2024
- |||||||||| Review, Journal: Nucleic acid-based vaccine platforms against the coronavirus disease 19 (COVID-19). (Pubmed Central) - Apr 4, 2023
Intracellular delivery of nucleic acid-based vaccines and their adverse events needs further research. Considering re-emergence of the COVID-19 variants of concern, vaccine reassessment and the development of polyvalent vaccines, or pan-coronavirus strategies, is essential for effective infection prevention.
- |||||||||| MEDI0457 / AstraZeneca, Avastin (bevacizumab) / Roche
Survival benefit to immunotherapy according to site of organ involvement in metastatic anal cancer. (On Demand | Level 1, West Hall; Poster Board No. A7) - Dec 13, 2022 - Abstract #ASCOGI2023ASCO_GI_676; These data provide historical context in estimating median PFS necessary for future trial design in patients with metastatic anal cancer. Lymph node-only distribution of distant metastatic disease was predictive for improved survival with immunotherapy.
- |||||||||| INO-4700 / GeneOne, Inovio
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: Safety, Tolerability and Immunogenicity of INO-4700 for MERS-CoV in Healthy Volunteers (clinicaltrials.gov) - Nov 21, 2022 P2, N=192, Active, not recruiting, While the primary efficacy endpoint was not reached, clinical benefit was encouraging. Recruiting --> Active, not recruiting | N=542 --> 192 | Trial completion date: Jun 2024 --> Nov 2022 | Trial primary completion date: Jun 2024 --> Nov 2022
- |||||||||| INO-4800 / Inovio, The Wistar Institute, INO-9112 / Inovio
Enrollment change, Trial withdrawal, Combination therapy: Safety, Tolerability and Immunogenicity of INO-4800 for COVID19 in Healthy Volunteers (clinicaltrials.gov) - Nov 17, 2022 P1, N=0, Withdrawn, Recruiting --> Active, not recruiting | N=542 --> 192 | Trial completion date: Jun 2024 --> Nov 2022 | Trial primary completion date: Jun 2024 --> Nov 2022 N=160 --> 0 | Not yet recruiting --> Withdrawn
- |||||||||| INO-A002 / Inovio
Trial completion: A Study of INO-A002 in Healthy Dengue Virus-naive Adults (clinicaltrials.gov) - Nov 8, 2022 P1, N=30, Completed, Active, not recruiting --> Completed | Trial primary completion date: May 2022 --> Oct 2022 Active, not recruiting --> Completed
- |||||||||| neoantigen DNA vaccine / Washington University School of Medicine in St. Louis, AstraZeneca
Enrollment closed, Trial completion date, Trial primary completion date: Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma (clinicaltrials.gov) - Oct 21, 2022 P1, N=9, Active, not recruiting, Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial completion date: Nov 2024 --> Apr 2023 | Trial primary completion date: Dec 2023 --> May 2022
- |||||||||| INO-4800 / Inovio, The Wistar Institute
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: INNOVATE: Safety, Immunogenicity, and Efficacy of INO-4800 for COVID-19 in Adults at High Risk of SARS-CoV-2 Exposure (clinicaltrials.gov) - Oct 13, 2022 P2/3, N=1308, Terminated, Recruiting --> Active, not recruiting | Trial completion date: Nov 2024 --> Apr 2023 | Trial primary completion date: Dec 2023 --> May 2022 N=7517 --> 1308 | Trial completion date: Feb 2023 --> Sep 2022 | Active, not recruiting --> Terminated | Trial primary completion date: Feb 2023 --> Sep 2022; The study was terminated to prioritize Inovio's COVID-19 efforts to advance a heterologous booster strategy and optimize potential impact on global public health.
- |||||||||| rocakinogene sifuplasmid (INO-9012) / Inovio, INO-5401 / Inovio
Trial completion date, Trial primary completion date, Combination therapy, Metastases: INO-5401 + INO-9012 in Combination With Atezolizumab in Locally Advanced Unresectable or Metastatic/Recurrent Urothelial Carcinoma (clinicaltrials.gov) - Oct 12, 2022 P1/2, N=35, Active, not recruiting, N=7517 --> 1308 | Trial completion date: Feb 2023 --> Sep 2022 | Active, not recruiting --> Terminated | Trial primary completion date: Feb 2023 --> Sep 2022; The study was terminated to prioritize Inovio's COVID-19 efforts to advance a heterologous booster strategy and optimize potential impact on global public health. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
- |||||||||| INO-4500 / Inovio
Trial completion, Combination therapy: Dose-ranging Study: Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers in Ghana (clinicaltrials.gov) - Oct 3, 2022 P1, N=220, Completed, While neither cohort A nor C were expanded due to insufficient clinical activity, the clinical responses seen with SBRT/FLT3L/polyICLC/nivolumab suggest sufficient clinical benefit that may warrant additional investigation, particularly the contribution of radiation to the responses observed. Active, not recruiting --> Completed
- |||||||||| Biomarker, Enrollment closed, Trial completion date, IO biomarker, Metastases: PORTER: Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel Combinations (clinicaltrials.gov) - Sep 28, 2022
P1, N=45, Active, not recruiting, Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial completion date: Mar 2023 --> Oct 2022
- |||||||||| INO-4800 / Inovio, The Wistar Institute, INO-9112 / Inovio
Trial completion date, Trial primary completion date, Combination therapy: Safety, Tolerability and Immunogenicity of INO-4800 for COVID19 in Healthy Volunteers (clinicaltrials.gov) - Aug 22, 2022 P1, N=160, Not yet recruiting, Recruiting --> Active, not recruiting | Trial completion date: Mar 2023 --> Oct 2022 Trial completion date: Aug 2023 --> Mar 2024 | Trial primary completion date: Aug 2023 --> Mar 2024
- |||||||||| INO-4800 / Inovio, The Wistar Institute
INO-4800 ? (Twitter) - Aug 20, 2022
- |||||||||| GNOS-PV02 / Geneos Therap, Keytruda (pembrolizumab) / Merck (MSD)
Personalized DNA neoantigen vaccine (GNOS-PV02) in combination with plasmid IL-12 and pembrolizumab as second-line (2L) treatment for advanced hepatocellular carcinoma (HCC) (205ABC) - Aug 4, 2022 - Abstract #SITC2022SITC_193; P1/2 Methods Patients with unresectable or metastatic HCC and progression or intolerance on first-line therapy with tyrosine kinase inhibitors (sorafenib or lenvatinib) are enrolled...Conclusions GNOS-PV02 + INO-9012 combined with pembrolizumab in the 2L setting was well tolerated and induced tumor-neoantigen-directed CD8+ T cells and TILs...Trial Registration NCT04251117 Ethics Approval For GT-30 trial, the protocols were approved by Johns Hopkins Medicine Review Boards (CR00039002/IRB00227771), Icahn School of Medicine-Program for the Protection of Human Subjects (20-00076 GCO#1), and Northern A Health and Disability Ethics committee (Ethics ref: 20/NTA), respectively. Written informed consent was obtained from each patient prior to the patient participating in the trial.
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