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- EXPLORING BLOOD-BRAIN BARRIER-PENETRATING DRUGS FOR THE IDENTIFICATION OF NOVEL THERAPIES IN GLIOBLASTOMA () - Oct 2, 2024 - Abstract #SIOP2024SIOP_1430;
This multi-faceted approach aims to develop personalized and effective treatment strategies for the challenging landscape of glioblastoma tumors. This work was supported by FAPESP grant numbers 2022/09037-3, National Council for Scientific and Technological Development (CNPq, MCTI, Brazil) grant number 406484/2022-8 (INCT BioOncoPed)
- | COG 133 / Cognosci, COG1410 / Cognosci
Preclinical, Journal: TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. (Pubmed Central) - Sep 14, 2024
In conclusion, TREM2 upregulation mitigates long-term cognitive dysfunction following SAH by attenuating hippocampal neuroinflammation via the PI3K/Akt signaling pathway. These findings suggest that TREM2 could be a potential therapeutic target for improving cognitive outcomes after SAH.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: TREM2, a critical activator of pyroptosis, mediates the anti?tumor effects of piceatannol in uveal melanoma cells via caspase 3/GSDME pathwayTREM2, a critical activator of pyroptosis, mediates the anti?tumor effects of piceatannol in uveal melanoma cells via caspase 3/GSDME pathway. (Pubmed Central) - Sep 2, 2024
Furthermore, PIC inhibited tumor growth via regulating the TREM2/caspase 3/GSDME pathway in a mouse model. Collectively, the present study revealed a novel mechanism underlying the inhibitory effects of PIC on UM, providing a potential treatment approach for UM in clinic.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: Precise Modulation of Pericyte Dysfunction by a Multifunctional Nanoprodrug to Ameliorate Alzheimer's Disease. (Pubmed Central) - Jun 4, 2024
Consequently, VLC@Cur-NPs markedly increased pericyte regeneration to form a positive feedback loop and thus improved neurovascular function and ultimately alleviated memory defects in APP/PS1 transgenic mice. We present a promising therapeutic strategy for AD that can precisely modulate pericytes and has the potential to treat other cerebrovascular diseases.
- | COG 133 / Cognosci, COG 112 / Cognosci
Journal: Engineered endolysin of Klebsiella pneumoniae phage is a potent and broad-spectrum bactericidal agent against "ESKAPEE" pathogens. (Pubmed Central) - May 24, 2024
Our findings advance the field of endolysin engineering, facilitating the customization of these proteins to target specific bacterial pathogens. This approach holds promise for the development of personalized therapies tailored to combat ESKAPEE infections effectively.
- | COG 133 / Cognosci, PLX5622 / Daiichi Sankyo, COG1410 / Cognosci
Preclinical, Journal: TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia. (Pubmed Central) - Apr 27, 2024
This approach holds promise for the development of personalized therapies tailored to combat ESKAPEE infections effectively. We demonstrate that TREM2 has the potential to alleviate WMI following TBI, possibly through the DHCR24/LXR pathway in microglia.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: ApoE Mimetic Peptide COG1410 Kills Mycobacterium smegmatis via Directly Interfering ClpC's ATPase Activity. (Pubmed Central) - Mar 27, 2024
This study sheds light on a unique resistance mechanism against AMPs in mycobacteria, highlighting the pivotal role of ClpC in this process. Unraveling the interplay between COG1410 and ClpC enriches our understanding of AMP-bacterial interactions, offering potential insights for developing innovative strategies to combat antibiotic resistance.
- | COG 133 / Cognosci, COG 112 / Cognosci
Journal: The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions. (Pubmed Central) - Feb 27, 2024
In conclusion, ApoE plays an important role in mediating the transport of fatty acids from neurons to astrocytes under ischemia/hypoxia conditions, and this transport mechanism is ApoE isoform dependent. ApoE4 has a low transfer efficiency and may be a potential target for the clinical treatment of neonatal hypoxic-ischemic encephalopathy.
- | COG 133 / Cognosci, COG1410 / Cognosci
Preclinical, Journal: Preclinical Evaluation of Tc-MAG-5-Fab Targeting TREM2 in Lung Cancer Mouse Models: A Comparison with Tc-MAG-5-F(ab'). (Pubmed Central) - Jan 2, 2024
The biodistribution results were consistent with the micro-SPECT/CT imaging results. Tc-MAG-5-Fab could clearly display hTREM2 A549 tumors in a short time (1 h) with low uptake in nontumor organs and tissues and thus has clinical application prospects.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: COG1410 regulates microglial states and protects retinal ganglion cells in retinal ischemia-reperfusion injury. (Pubmed Central) - Nov 27, 2023
The expression of TREM2 showed an increasing trend after COG1410 administration, but it was not statistically significant. In conclusion, COG1410 regulates microglial states and protects RGCs in retinal IR injury, showing promising potential for the treatment of eye diseases.
- | COG 133 / Cognosci, COG 112 / Cognosci
Journal: Controlled Release of a Therapeutic Peptide in Sprayable Surgical Sealant for Prevention of Postoperative Abdominal Adhesions. (Pubmed Central) - Mar 9, 2023
Two independent mouse models of cecal ligation and cecal anastomosis significantly reduced adhesion severity versus Seprafilm, COG133 liquid suspension, and no treatment control. The synergy of physical and chemical methods in a barrier material with proven preclinical studies highlights the value of COG133-loaded PLCL fiber mats in effectively dampening the formation of severe abdominal adhesions.
- | COG 133 / Cognosci, COG1410 / Cognosci
Preclinical, Journal: Apolipoprotein E mimetic peptide COG1410 alleviates blood?brain barrier injury in a rat model of ischemic stroke. (Pubmed Central) - Mar 8, 2023
The mechanism of COG1410 was found to be mediated, as least partly, through the activation of triggering receptor expressed on myeloid cells 2. In conclusion, the data suggest that COG1410 can alleviate BBB injury and neuroinflammation following ischemic stroke.
- | COG 133 / Cognosci, COG1410 / Cognosci
Preclinical, Journal, IO biomarker: TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice. (Pubmed Central) - Dec 4, 2022
Altogether, we are the first to demonstrate that TREM2 activation by COG1410 alleviated neural damage through activation of Akt/CREB/BDNF signalling axis in microglia after CCI. Finally, COG1410 treatment improved neurological behaviour and brain electrophysiological activity after CCI.
- | COG 133 / Cognosci, COG 112 / Cognosci
Journal, PD(L)-1 Biomarker, IO biomarker: Inhibition of APOE potentiates immune checkpoint therapy for cancer. (Pubmed Central) - Sep 30, 2022
Furthermore, APOE expression in cancer patients resistant to αPD-1 treatment significantly exceeded that in the sensitive group. For this reason, APOE is likely to be targeted for modifying tumor macrophage infiltrate and augmenting checkpoint immunotherapy.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: Apolipoprotein E mimetic peptide COG1410 combats pandrug-resistant Acinetobacter baumannii. (Pubmed Central) - Sep 13, 2022
elegans infection model showed that combined therapy of COG1410 and polymyxin B was capable of significantly rescuing the infected nematodes. Taken together, our study demonstrates that COG1410 is a promising drug candidate in the battle against pandrug-resistant A. baumannii.
- | COG 133 / Cognosci, COG1410 / Cognosci
Preclinical, Journal: Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice. (Pubmed Central) - Aug 30, 2022
Thus, our study suggested that LRP1 activation with COG1410 attenuated cerebral I/R injury at least partially related to modulating microglial polarization through TXNIP/NLRP3 signaling pathway in mice. Thus, COG1410 treatment might serve as a promising therapeutic approach in the management of cerebral I/R patients.
- | COG 133 / Cognosci, COG 112 / Cognosci
Preclinical, Journal, CAR T-Cell Therapy: Nonviral mcDNA-mediated bispecific CAR T cells kill tumor cells in an experimental mouse model of hepatocellular carcinoma. (Pubmed Central) - Jul 27, 2022
CoG133-CAR T cells have enhanced tumor-suppression capacity through dual antigen recognition and internal activation. It provides an innovative strategy for CAR T therapy of HCC, even solid tumors.
- | COG 133 / Cognosci, COG 112 / Cognosci
Journal: COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage. (Pubmed Central) - May 6, 2022
In terms of molecular mechanism, COG133 inhibits blood-brain barrier destruction through the proinflammatory CypA-NF-κB-MMP9 pathway and reduces neuronal pyroptosis by inhibiting NLRP3 inflammasome activation. In conclusion, this study demonstrated that apoE-mimetic peptide, COG133, can play a neuroprotective role by protecting blood-brain barrier function and inhibiting brain cell pyroptosis to reduce early brain injury after subarachnoid hemorrhage.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: Synthesis and Evaluation of Ga-NOTA-COG1410 Targeting to TREM2 of TAMs as a Specific PET Probe for Digestive Tumor Diagnosis. (Pubmed Central) - Mar 15, 2022
The data testified that Ga-NOTA-COG1410 was a specific radioligand targeting TREM2, which could be used to distinguish tumors from inflammation. Using Ga-NOTA-COG1410, the effectiveness of PET on digestive tumors imaging may be enhanced.
- | COG 133 / Cognosci, SF2523 / SignalRx, COG 112 / Cognosci
Journal: Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma. (Pubmed Central) - Nov 17, 2021
Moreover, systemic administration of COG-133-NPs loaded with MDB5 and SF2523 resulted in decreased tumor burden compared to non-targeted drug-loaded NPs, without any hepatic toxicity. In conclusion, our nanomedicine of MDB5 and SF2523 offers a novel therapeutic strategy to treat chemoresistant MB.
- | COG 112 / Cognosci
Preclinical, Journal: Effect of electroacupuncture on inhibition of inflammatory response and oxidative stress through activating ApoE and Nrf2 in a mouse model of spinal cord injury. (Pubmed Central) - Nov 4, 2021
In conclusion, our nanomedicine of MDB5 and SF2523 offers a novel therapeutic strategy to treat chemoresistant MB. These results suggest that electroacupuncture protects neurons and myelinated axons following spinal cord injury through an ApoE-dependent mechanism.
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: Multifunctional nanorods based on self-assembly of biomimetic apolipoprotein E peptide for the treatment of Alzheimer's disease. (Pubmed Central) - Aug 13, 2021
As a result, the delivery system significantly enhances the delivery of MOP to the brain, thus reducing Aβ deposition, mitigating the memory deficits, and ameliorating neurologic damage in AD model mice. Our findings suggest that our drug and carrier integrated multifunctional delivery system has the potential for AD treatment.
- | COG 133 / Cognosci, quercetin (LY294002) / Eli Lilly, COG1410 / Cognosci
Preclinical, Journal, IO biomarker: TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice. (Pubmed Central) - Apr 1, 2021
Our finding demonstrated that TREM2 activation improved neurological functions and attenuated neuroinflammation and neuronal apoptosis after ICH, which was, at least in part, mediated by activation of PI3K/Akt signaling pathway. Therefore, activation of TREM2 may be a potential therapeutic strategy for the management of ICH patients.
- | COG 133 / Cognosci, fluorouracil / Generic mfg., COG 112 / Cognosci
Journal: WNT / β-catenin pathway in recovering IEC-6 intestinal cells after 5-FU induced injury and treatment with mimetic peptide APOE COG133. (Pubmed Central) - Feb 23, 2020
Therefore, activation of TREM2 may be a potential therapeutic strategy for the management of ICH patients. No abstract available
- | Journal: Evaluation of the mimetic peptide APOE COG1410 in the viability, migration, and apoptosis of the intestinal cells IEC-18 after injuries by 5-FU. (Pubmed Central) - Feb 23, 2020
No abstract available No abstract available
- | COG 133 / Cognosci, COG1410 / Cognosci
Journal: Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. (Pubmed Central) - Oct 15, 2019
COG1410 significantly prevented the decrease in visual from ever occurring, attenuated inflammation and apoptosis, and reduced optic nerve edema and RGC apoptosis compared with vehicle treatment. These data identify protective roles of COG1410 in the inflammatory and apoptotic processes of TONI, as well as strategies for its treatment.
- | COG 133 / Cognosci, COG1410 / Cognosci
Biomarker, Preclinical, Journal: LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats. (Pubmed Central) - Apr 3, 2019
LRP1 activation attenuated WMI and improved neurological function by modulating M2 microglial polarization at least in part through Shc1/PI3K/Akt signaling in a rat model of SAH. The apoE-mimic peptide COG1410 may serve as a promising treatment in the management of SAH patients.