- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: CAST: Cardiac Safe Transplants for Systemic Sclerosis (clinicaltrials.gov) - Aug 12, 2020 P2/3, N=9, Terminated, Trial completion date: Jul 2022 --> Sep 2020 N=50 --> 9 | Trial completion date: Jan 2026 --> Oct 2019 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2025 --> Oct 2019; PI Sabbatical
- |||||||||| autologous hematopoietic stem cell therapy / Northwestern University
Trial completion, Trial completion date: Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy (clinicaltrials.gov) - Jul 23, 2020 P2, N=80, Completed, N=50 --> 9 | Trial completion date: Jan 2026 --> Oct 2019 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2025 --> Oct 2019; PI Sabbatical Active, not recruiting --> Completed | Trial completion date: Jul 2020 --> Nov 2019
- |||||||||| SB-001 / Solid BioSciences, SB-002 / Solid BioSciences
Journal: Variability in the immunogenic preS region of Pakistani hepatitis B virus isolates. (Pubmed Central) - Dec 8, 2019 Sequencing results showed that eight samples (SBS002-SBS008) have a deletion of 33 nucleotides at N-terminal that is characteristics of genotype D while SBS001 belongs to genotype C. Silent mutations and amino acid changes were also searched in this highly variable region of genome. Based upon this study it was concluded that genotype D is the most common genotype in Pakistan.
- |||||||||| autologous hematopoietic stem cell therapy / Northwestern University
Trial completion date, Trial primary completion date: Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy (clinicaltrials.gov) - Nov 10, 2019 P2, N=80, Active, not recruiting, Based upon this study it was concluded that genotype D is the most common genotype in Pakistan. Trial completion date: Jan 2020 --> Jul 2020 | Trial primary completion date: Dec 2018 --> Jul 2019
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
Enrollment change, Trial withdrawal: ATTEND: Autologous Transplant To End NMO Spectrum Disorder (clinicaltrials.gov) - Nov 8, 2019 P2/3, N=0, Withdrawn, Trial completion date: Jan 2020 --> Jul 2020 | Trial primary completion date: Dec 2018 --> Jul 2019 N=50 --> 0 | Recruiting --> Withdrawn
- |||||||||| CLD-101 / Calidi Biotherap
Trial completion date, Trial primary completion date, Oncolytic virus: Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma (clinicaltrials.gov) - Aug 28, 2019 P1, N=36, Recruiting, Additionally, pre-treatment with a checkpoint inhibitor prior to autoHSCT appears safe thus far and does not appear to delay engraftment. Trial completion date: Apr 2019 --> Apr 2020 | Trial primary completion date: Mar 2019 --> Mar 2020
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
Trial initiation date: ATTEND: Autologous Transplant To End NMO Spectrum Disorder (clinicaltrials.gov) - Jul 25, 2019 P2/3, N=50, Recruiting, Trial completion date: Apr 2019 --> Apr 2020 | Trial primary completion date: Mar 2019 --> Mar 2020 Initiation date: Jun 2019 --> Nov 2019
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
Enrollment closed: CAST: Cardiac Safe Transplants for Systemic Sclerosis (clinicaltrials.gov) - Jul 25, 2019 P2/3, N=50, Active, not recruiting, Initiation date: Jun 2019 --> Nov 2019 Recruiting --> Active, not recruiting
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
Trial initiation date: ATTEND: Autologous Transplant To End NMO Spectrum Disorder (clinicaltrials.gov) - May 2, 2019 P2/3, N=50, Recruiting, Recruiting --> Active, not recruiting Initiation date: Mar 2019 --> Jun 2019
- |||||||||| SB-001 / Solid BioSciences
Journal: Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent. (Pubmed Central) - Apr 19, 2019 MTH1 was identified by both TS-FITGE and TPP, and SB2001 inhibited the function of MTH1 in hydrolyzing oxidized nucleotides. Compared to CaSki cells, HeLa cells displayed downregulated DNA mismatch repair pathways, which made HeLa cells more susceptible to the oxidative stress caused by SB2001, resulting in increased 8-oxoG concentrations, DNA damage, and subsequent cell death.
- |||||||||| Triapine (3-AP) / Vion, Northwestern University
Phase classification, Enrollment change, Trial primary completion date, Combination therapy, Metastases: NRG-GY006: Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers (clinicaltrials.gov) - Apr 9, 2019 P3, N=348, Recruiting, Compared to CaSki cells, HeLa cells displayed downregulated DNA mismatch repair pathways, which made HeLa cells more susceptible to the oxidative stress caused by SB2001, resulting in increased 8-oxoG concentrations, DNA damage, and subsequent cell death. Phase classification: P2 --> P3 | N=188 --> 348 | Trial primary completion date: Sep 2018 --> Jul 2023
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
Enrollment closed, Enrollment change: Stem Cell Transplantation for Stiff Person Syndrome (SPS) (clinicaltrials.gov) - Jan 31, 2019 P1/2, N=23, Active, not recruiting, Phase classification: P2 --> P3 | N=188 --> 348 | Trial primary completion date: Sep 2018 --> Jul 2023 Recruiting --> Active, not recruiting | N=40 --> 23
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, autologous hematopoietic stem cell therapy / Northwestern University
New P2/3 trial: CAST: Cardiac Safe Transplants for Systemic Sclerosis (clinicaltrials.gov) - Jul 20, 2018 P2/3, N=50, Recruiting,
- |||||||||| Triapine (3-AP) / Vion, Northwestern University
Trial initiation date, Trial suspension, Combination therapy, Metastases: NRG-GY006: Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers (clinicaltrials.gov) - Jan 8, 2018 P2, N=188, Suspended, Recruiting --> Active, not recruiting Initiation date: Aug 2017 --> Jan 2016 | Recruiting --> Suspended
- |||||||||| Enrollment change, Trial termination, Trial primary completion date: Hematopoietic Stem Cell Support in Vasculitis (clinicaltrials.gov) - Jul 13, 2016
P1, N=7, Terminated, N=10 --> 7 | Recruiting --> Terminated | Trial primary completion date: Aug 2017 --> Jun 2016; No participant enrolled over five years. No plan to continue the study.
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