Advancell 
Welcome,         Profile    Billing    Logout  
 2 Products   1 Disease   0 Trials   28 News 
  • ||||||||||  BX002 / BiomX, ciclosporin topical (ATH 002) / ISDIN, Advancell
    HIGHCO : TRANSACTIONS SUR ACTIONS PROPRES DU 28/01/2019 AU 01/02/2019 (GBN) -  Feb 9, 2019   
    In conclusion, the side effects of high Aca doses preclude its use in patients with strong comorbidities. Déclaration des transactions sur actions propresRéalisées du 28 janvier au 1er février 2019
  • ||||||||||  BX002 / BiomX, ciclosporin topical (ATH 002) / ISDIN, Advancell
    HIGHCO : TRANSACTIONS SUR ACTIONS PROPRES DU 28/01/2019 AU 01/02/2019 (GBN) -  Feb 4, 2019   
    Déclaration des transactions sur actions propresRéalisées du 28 janvier au 1er février 2019 Déclaration des transactions sur actions propresRéalisées du 28 janvier au 1er février 2019
  • ||||||||||  Protara (acadesine) / Teva
    Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress (ASH 2018) -  Dec 4, 2018 - Abstract #1321; Author: Guangyan C Sun, PhD1*; Anna C Shvab1*; Bin C Li, PhD2*; Felipe C Beckedorff3*; Guy Jacques Leclerc, PhD1*; Ramin Shiekhattar, PhD4*; Julio C Barredo, MD1,5,6,7; Presentation Time: December 01, 2018; 18:15-20:15   
    Finally, ChIP-qPCR experiments uncovered that the acadesine/PKD1 axis regulates the recruitment of nuclear factor-κB (NF-κB) to the promoter region of selected IEGs. Consequently, we have identified a novel, AMPK-independent transcription regulation mechanism of acadesine thorugh PKD1 in ALL cells, and co-targeting PDK1 and other pro-survival stress response pathways in ALL cells vulnerable to energy/metabolic stress offers potential novel strategies to overcome therapeutic resistance.
  • ||||||||||  Acadra (acadesine) / Advancell, Protara (acadesine) / Teva
    Journal:  Synthesis of C-labeled 5-Aminoimidazole-4-carboxamide-1-β-D-[ C ] ribofuranosyl 5'-monophosphate. (Pubmed Central) -  Apr 17, 2018   
    Our method employs a hybrid enzymatic and chemical synthesis approach that applies an enzymatic conversion from adenosine to inosine followed by a ring-cleavage of the protected inosine. A direct phosphorylation of the resulting 2',3'-isopropylidine acadesine (5) was developed to yield the title compound in 99% purity following ion exchange chromatography.
  • ||||||||||  sirolimus / Generic mfg., metformin / Generic mfg.
    Journal:  The role of AMPK/mTOR modulators in therapy of acute myeloid leukemia. (Pubmed Central) -  Jul 14, 2017   
    Although most of these pharmacological modulators have been widely used for decades, their mechanism of action is only partially understood. In this review, we summarize the role of AMPK and mTOR in hematological malignancies and discuss the possible role of pharmacological modulators in proliferation and differentiation of leukemia cells.
  • ||||||||||  Acadra (acadesine) / Advancell, Protara (acadesine) / Teva
    Journal:  AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. (Pubmed Central) -  Feb 19, 2017   
    However, mitochondrial instability and apoptosis were caused by AICAR along with an unexpected decrease in INH-induced cytoprotective autophagy. Therefore, AICAR failed to alleviate INH-caused mitochondrial instability in HepG2 cells due to its inhibitory effect on autophagy induced by INH.
  • ||||||||||  Torin1 / InvivoGen, Protara (acadesine) / Teva, Acadra (acadesine) / Advancell
    AUTOPHAGY IS CRITICAL FOR GOBLET CELLS TO MAINTAIN HOMEOSTASIS UNDER HIGH METABOLIC STRESS (CDDW 2017) -  Feb 18, 2017 - Abstract #A264; Author: S. Tiwari1, F. Moreau3, K. Chadee2; Presentation Time: MARCH 05, 2017; 18:00-19:30   
    The interplay between autophagy with AMPK signaling helps to maintain homeostasis in intestinal epithelial cells. This study demonstrates that impaired autophagy in high MUC2 mucin-producing cells might be a cellular defense to enhance cell survival.
  • ||||||||||  Acadra (acadesine) / Advancell
    Enrollment change; P1/2 data; Trial primary completion date; Trial termination:  GFM-Acadesine: A Phase I-II Trial of Acadesine (clinicaltrials.gov) -  Nov 7, 2016   
    P1/2,  N=5, Terminated, 
    N=30 -> 5 | Suspended -> Terminated | Trial primary completion date: Jun 2015 -> Jun 2013; Renal toxicity
  • ||||||||||  Acadra (acadesine) / Advancell, Protara (acadesine) / Teva
    Journal:  AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells. (Pubmed Central) -  Nov 4, 2016   
    Contrarily, salubrinal (the ER stress inhibitor), z-ATAD-fmk (the caspase-12 inhibitor) or CHOP shRNAs significantly attenuated AICAR-induced gallbladder cancer cell apoptosis. Together, we conclude that AICAR-induced gallbladder cancer cell apoptosis requires ER stress activation, but is independent of AMPK.
  • ||||||||||  Acadra (acadesine) / Advancell, Protara (acadesine) / Teva
    Journal:  AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. (Pubmed Central) -  Oct 22, 2016   
    In contrast, either autophagy activator rapamycin or AMPK activator acadesine (AICAR) compromised OA-induced anti-cancer effect. Our findings suggested that OA induced protective autophagy through AMPK-mTOR-ULK1 signaling pathway in bladder cancer cells and OA in combination with autophagy inhibitor might be a novel alternative for the treatment of bladder cancer.
  • ||||||||||  Protara (acadesine) / Teva, sirolimus / Generic mfg., Acadra (acadesine) / Advancell
    Journal:  AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. (Pubmed Central) -  Oct 22, 2016   
    In contrast, either autophagy activator rapamycin or AMPK activator acadesine (AICAR) compromised OA-induced anti-cancer effect. Our findings suggested that OA induced protective autophagy through AMPK-mTOR-ULK1 signaling pathway in bladder cancer cells and OA in combination with autophagy inhibitor might be a novel alternative for the treatment of bladder cancer.
  • ||||||||||  cyclosporine / Generic mfg., Protara (acadesine) / Teva, Acadra (acadesine) / Advancell
    Journal:  AICAR induces AMPK-independent programmed necrosis in prostate cancer cells. (Pubmed Central) -  Apr 12, 2016   
    ROS scavengers (N-acetylcysteine and MnTBAP), but not AMPKα shRNAs, largely inhibited prostate cancer cell necrosis and cytotoxicity by AICAR. In summary, the results of the present study demonstrate mechanistic evidences that AMPK-independent programmed necrosis contributes to AICAR's cytotoxicity in prostate cancer cells.
  • ||||||||||  Acadra (acadesine) / Advancell, Venclexta (venetoclax) / Roche, AbbVie
    Journal:  Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199. (Pubmed Central) -  Mar 23, 2015   
    This effect was validated in vivo, where the combination of both agents displayed a more marked inhibition of tumor outgrowth than each drug alone. These findings support the notions that antiapoptotic proteins of the Bcl-2 family regulate MCL cell sensitivity to acadesine and that the combination of this agent with Bcl-2 inhibitors might be an interesting therapeutic option to treat MCL patients.
  • ||||||||||  Acadra (acadesine) / Advancell
    Journal:  Predictors of contemporary coronary artery bypass grafting outcomes. (Pubmed Central) -  Mar 25, 2014   
    Recognition of patients with excessive atherosclerotic burden may permit perioperative interventions to improve their outcomes. The contemporary risks of coronary artery bypass grafting have changed, and their identification may permit new methods to improve outcomes.
  • ||||||||||  diazoxide (ATH-012) / Neurotec Pharma, Advancell
    Trial completion:  A Phase IIa Study of NT-KO-003 for Multiple Sclerosis (clinicaltrials.gov) -  Mar 15, 2014   
    P2a,  N=99, Completed, 
    Active, not recruiting -> Completed
  • ||||||||||  Acadra (acadesine) / Advancell
    P1/2 data; Trial suspension:  GFM-Acadesine: A Phase I-II Trial of Acadesine (clinicaltrials.gov) -  Mar 12, 2014   
    P1/2,  N=5, Suspended, 
    Recruiting -> Suspended
  • ||||||||||  Acadra (acadesine) / Advancell
    New P1/2 trial; P1/2 data:  GFM-Acadesine: A Phase I-II Trial of Acadesine (clinicaltrials.gov) -  Mar 18, 2013   
    P1/2,  N=5, Suspended,