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Preclinical efficacy and rationale of targeting lysine280-acetylated tau for Alzheimer (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_3661; Based on our observations that tau-acK280 is a core species involved in seeding and propagation activities, the Y01 antibody that specifically recognizes acK280 represents a promising therapeutic candidate for AD and other neurodegenerative diseases associated with tauopathy. ADEL-Y01 is currently undergoing a phase-1 clinical trial in the United States through a collaborative effort between ADEL and Oscotec.
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