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Journal: Nanoparticle-coupled topical methotrexate can normalize immune responses and induce tissue remodeling in psoriasis. (Pubmed Central) - Jan 8, 2021
We show that MTX coupled with gold nanoparticles (GNPs) demonstrates superior antiinflammatory efficacy than MTX alone in an imiquimod-induced mouse model, significantly reducing γδ T cells, CD4 T cells, and neutrophils...In an AGR129 human xenograft mouse model, two-week topical treatment with MTX-GNPs inhibited skin hyperplasia significantly better than topical calcipotriol-betamethasone and led to profound tissue remodeling, involving the upregulation of extracellular matrix reorganization and the downregulation of cornification and keratinization processes...In conclusion, MTX-GNPs influence immune and stromal components of the skin, leading to potent inhibition of pathogenesis in preclinical psoriasis. MTX-GNPs surpass the efficacy of conventional MTX and standard of care, emerging as a non-steroidal, topical alternative for psoriasis treatment.
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Clinical, Journal: Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature. (Pubmed Central) - Apr 10, 2020
Significant improvement of the lesion with no local or systemic side effects were noted during the course of therapy. We propose that this well-tolerated drug can be used for vitiligo therapy; however, further investigations should be performed to ascertain the exact topically effective dose.
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Preclinical, Journal: Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model. (Pubmed Central) - Nov 23, 2019
Blood evaluation showed no differences in blood count and in ALT and AST levels before and after AuNPs-3MPS or AuNPs-3MPS@MTX treatment. Topical AuNPs-3MPS@MTX treatment is able to induce a reduction of keratinocytes hyperproliferation, epidermal thickness and also inflammatory infiltrate in vivo on imiquimod-induced psoriasis like mice model.
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Trial completion: Efficacy and Safety of Vascana® in Subjects With Secondary Raynaud's Phenomenon (clinicaltrials.gov) - Feb 23, 2017
P2, N=65, Completed,
Topical AuNPs-3MPS@MTX treatment is able to induce a reduction of keratinocytes hyperproliferation, epidermal thickness and also inflammatory infiltrate in vivo on imiquimod-induced psoriasis like mice model. Not yet recruiting --> Completed
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