- |||||||||| HL144 / Daewoong Pharma
[VIRTUAL] Hypoxemia During Sleep Disordered Breathing and Cardiovascular Disease: A Comparison of Different Oxygen Desaturation Measures () - Sep 12, 2020 - Abstract #Sleep2020SLEEP_400;
However, after covariate adjustment, only shorter average desaturation duration, and higher hypoxic burden and Tlt 90% were independent CV risk factors. Support: AASM Foundation (194-SR-18,188-SR-17); American Heart Association (19CDA34660137); NIH (U01HL53940,U 01HL53941,U01HL63463,U01HL53937, U01HL53938,U01H L53916,U01HL53934,U01HL63429,U01HL53931,HL114473, P01HL094307,HL134015,R35HL135818,1R21HL145492- 01,R01HL102321,R01HL128658); The State Research Funding (KUH: 5041767, 5041768; TUH: VTR3242, VTR3228, EVO2089), Academy of Finland (313697, 323536), Business Finland (5133/31/2018), Respiratory Foundation of Kuopio Region, Tampere Tuberculosis Foundation, Research Foundation of Pulmonary Diseases, Foundation of Finnish Anti-Tuberculosis Association.
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[VIRTUAL] SIRT3 Promotes Resolution of Persistent Lung Fibrosis Associated with Aging (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_310;
These studies provide a premise to elucidate the primary molecular targets and activities through which SIRT3 exerts its protective and anti-fibrotic effects. Grants: NIH grants, P01 HL114470 and R01 AG046210; and a VA Merit Award, I01BX003056.
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Aconitate Decarboxylase-1 Deficiency Promotes Bacterial Dissemination During Intrapulmonary Klebsiella Pneumoniae Infection (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area J) - Mar 15, 2020 - Abstract #ATS2020ATS_9095;
The host protective mechanism of ACOD1 may be due, in part, through secretion of itaconate and direct antimicrobial effect against KP.This abstract is funded by: National Institutes of Health, Burroughs Wellcome Fund, Winters Foundation Grant (to T.L.S.), National Institutes of Health P01 HL114453 (to R.K.M. and J.S.L.), S10OD023402 (to S.G.W.), R01 HL142084 and K24 HL14285 (to J.S.L.).
- |||||||||| bleomycin / Generic mfg., BMS, HL144 / HanAll Biopharma
Age-Associated ATP Citrate Lyase Deficiency Induces Resistance to Apoptosis in Myofibroblasts and Impairs Fibrosis Resolution (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area E) - Mar 15, 2020 - Abstract #ATS2020ATS_7447;
A more sustained downregulation of ACLY is observed after injury in aged mice, which exhibit a diminished capacity for fibrosis resolution. Therapeutic reconstitution of ACLY expression may represent a metabolic strategy to restore sensitivity to myofibroblast apoptosis and to accelerate fibrosis resolution.Funding: NIH grants; P01 HL114470 and R01 AG046210 (VJT), T32 5T32HL134640-02 (SRS), and VA Merit Award I01BX003056 (VJT)
- |||||||||| bleomycin / Generic mfg., BMS, HL144 / HanAll Biopharma
SIRT3 Promotes Resolution of Persistent Lung Fibrosis Associated with Aging (PENNSYLVANIA CONVENTION CENTER, Room 118 A (100 Level)) - Mar 15, 2020 - Abstract #ATS2020ATS_2984;
Our results indicate that SIRT3 deficiency contributes to the reduced capacity for resolution of fibrosis associated with aging based on the following observations: (1) SIRT3 expression is decreased in IPF; (2) SIRT3 is suppressed during the fibrogenic phase of lung injury; (3) SIRT3 deficiency leads to senescence and apoptosis resistance; and (4) over-expression of SIRT3 promotes resolution and reverses established fibrosis in mice. These studies provide a premise to elucidate the primary molecular targets and activities through which SIRT3 exerts its protective and anti-fibrotic effects.Grants:NIH grants, P01 HL114470 and R01 AG046210; and a VA Merit Award, I01BX003056.
- |||||||||| HL144 / HanAll Biopharma, Miostat (carbachol) / Novartis
TMEM16A Modulates TGFβ1-Induced MLC2 Phosphorylation in Human Airway Smooth Muscle (PENNSYLVANIA CONVENTION CENTER, Room 204 A-B (200 Level)) - Mar 15, 2020 - Abstract #ATS2020ATS_2585;
Previously, we have shown that TGF-β1 significantly increases carbachol (CCh)-induced [Ca2+]i levels, myosin light chain 2 (MLC2) and myosin phosphatase target subunit 1 (MYPT1) phosphorylation levels and augments CCh-induced bronchoconstriction. These results suggest a significant role for CaCCs, specifically TMEM16A, in TGF-β1-induced MLC2 phosphorylation and CCh-induced HASM contraction.Supported by NIH funding 2P01HL114471-06 and 1UL1TR003017-01
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Journal: NF-YB1-YC12-bHLH144 complex directly activates Wx to regulate grain quality in rice (Oryza sativa L.). (Pubmed Central) - Mar 2, 2020
NF-YC12 and bHLH144 maintain NF-YB1 stability from the degradation mediated by ubiquitin/26S proteasome, while NF-YB1 directly binds to the "G-box" domain of Wx promoter and activates Wx transcription, hence to regulate rice grain quality. In all, we revealed a novel grain quality regulatory pathway controlled by NF-YB1-YC12-bHLH144 complex, which has great potential for rice genetic improvement.
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