ibuprofen / Generic mfg. 
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  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  Enhanced Solubility of Ibuprofen by Complexation with ?-Cyclodextrin and Citric Acid. (Pubmed Central) -  Apr 17, 2024   
    As a result, ternary ?-CD/IBU/CA complex formed by initial incorporation of ibuprofen into ?-CD, followed by successive formation of a two-phase mixture with CA, exhibited notably improved dissolution kinetics compared to the pure ibuprofen and slightly better compared to the binary ?-CD/IBU system. Although the addition of CA to ?-CD/IBU does not significantly increase the solubility rate of IBU, it must be considered that the amount of ?-CD is significantly less in the ternary complex compared to the binary ?-CD/IBU.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  Early Treatment of Patent Ductus Arteriosus with Ibuprofen. Reply. (Pubmed Central) -  Apr 14, 2024   
    Combined with the PopPK model, this method was applied to rapidly analyze the concentrations of NSAIDs in clinical samples from patients presenting to the emergency department with acute liver dysfunction and monitored NSAIDs clinical safety. No abstract available
  • ||||||||||  ibuprofen / Generic mfg.
    Preclinical, Journal:  Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model. (Pubmed Central) -  Apr 14, 2024   
    The PD rats were administered GGD or Ibuprofen (positive control) intragastrically once daily for seven consecutive days...The results of this study suggest that GGD alleviates PD in rats by suppressing the COX-2-mediated release of PGE2 and PGF2?, modulating the ER?/ERK1/2/COX-2 pathway, and increasing ?-EP content. These results provide insights into the potential mechanisms of GGD in treating PD and support its further investigation as an alternative therapy for this condition.
  • ||||||||||  mefenamic acid / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Dentists' attitudes and prescription practices for analgesics and antibiotics in Kirkuk Governorate, Iraq. (Pubmed Central) -  Apr 12, 2024   
    The first-choice analgesic for 44.6% of dentists was mefenamic acid, followed by paracetamol (31.1%)...Dentists in Kirkuk City showed variations in knowledge and awareness regarding using analgesics and antibiotics. This requires further education and training on proper analgesics and antibiotic stewardship guidelines.
  • ||||||||||  Journal:  Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells. (Pubmed Central) -  Apr 9, 2024   
    The cytochrome P450 (CYP) family serves a critical role in the metabolism of numerous essential drugs (such as tamoxifen, ibuprofen and phenytoin), where the majority of drug interactions involve CYP-mediated metabolism...Results in the present study suggest that TSS can inhibit CYP3A4 mRNA and protein expression, but exerts opposite effects on their CYP1A2 counterparts. These findings suggest that it is necessary to consider drug interactions between clinical preparations containing TSS or Bupleurum and drugs metabolized by CYP3A4 and CYP1A2 to avoid potential adverse drug reactions in clinical practice.
  • ||||||||||  Journal:  Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates. (Pubmed Central) -  Apr 8, 2024   
    This review summarizes the antiproliferative activity of derivatives of NSAIDs such as Diclofenac, Etodolac, Celecoxib, Ibuprofen, Tolmetin, and Sulindac, published between 2017 and 2023. Their mechanism of action and structural activity relationships (SARs) were also discussed to set the path for potential future repositioning of NSAIDs for clinical deployment in the treatment of cancer.
  • ||||||||||  Halfan (halofantrine) / GSK
    Preclinical, Journal:  Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats. (Pubmed Central) -  Apr 5, 2024   
    Similar to other tissues, the lymphatics may thus play a significant role in the transport of macromolecules, including therapeutic proteins, from the brain but are unlikely to be a major transport pathway from the brain for small molecule drugs that are not lipophilic. Our rat cervical lymph cannulation model can be used to quantify the lymphatic drainage of different molecules and factors from the brain.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  Spatial Arrangement of the Drug Ibuprofen in a Model Membrane in the Presence of Lipid Rafts. (Pubmed Central) -  Apr 5, 2024   
    20 mol %, the results show that ibuprofen-SL molecules have a quasi-regular lateral distribution, with a "superlattice" parameter of ?3.0 nm. This regularity can be explained by the entrapment of ibuprofen-SL molecules by lipid rafts known to exist in this system with the additional assumption that lipid rafts have a nanoscale substructure.
  • ||||||||||  ibuprofen / Generic mfg.
    Preclinical, Journal:  Mechanistic Modeling of In Vitro Biopharmaceutic Data for a Weak Acid Drug: A Pathway Towards Deriving Fundamental Parameters for Physiologically Based Biopharmaceutic Modeling. (Pubmed Central) -  Apr 4, 2024   
    The objective of this tutorial is to (1) review processes and parameters contributing to oral drug absorption in increasing levels of complexity, (2) outline a general physiologically based biopharmaceutic modeling workflow for weak acids, and (3) illustrate the outlined concepts via an ibuprofen (i.e., a weak, poorly soluble acid) case example in order to provide practical guidance on how to integrate biopharmaceutic and physiological data to better understand oral drug absorption. In the future, we plan to explore the usefulness of this tutorial/roadmap to inform the development of PBPK models for BCS 2 weak bases, by expanding the stepwise modeling approach to accommodate more intricate scenarios, including the presence of diprotic basic compounds and acidifying agents within the formulation.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  Direct Assembly of Bioactive Nanoparticles Constructed from Polyphenol-Nanoengineered Albumin. (Pubmed Central) -  Apr 4, 2024   
    Notably, ibuprofen-UNP nanoparticles exhibit a 5-fold increase in half-life compared with free ibuprofen, enhancing in vivo analgesic and anti-inflammatory effectiveness. This research establishes a versatile platform for protein-based nanosized materials accommodating various therapeutic agents in biotechnological applications.
  • ||||||||||  ibuprofen / Generic mfg., naproxen / Generic mfg.
    Journal:  Role for Carboxylic Acid Moiety in NSAIDs: Favoring the Binding at Site II of Bovine Serum Albumin. (Pubmed Central) -  Apr 4, 2024   
    Apart from BSA, we conducted some experimental studies with human serum albumin, and similar results were obtained, suggesting a general effect for other mammalian serum albumins. Our findings support that the RCOOH moiety affects not only the mechanism of action and side effects but also the pharmacokinetics of NSAIDs.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  ?-Methylacyl-CoA Racemase from Mycobacterium tuberculosis-Detailed Kinetic and Structural Characterization of the Active Site. (Pubmed Central) -  Apr 1, 2024   
    No significant change outside the enzymatic active site was observed in the three mutants, establishing that the diminution of catalytic activity is mainly attributable to disruption of the catalytic apparatus involving key hydrogen bonding and water-mediated interactions. The wild-type structure, together with detailed mutational and biochemical data, provide a basis for understanding the catalytic properties of this enzyme, which is important for the design of future anti-tuberculosis drug molecules.
  • ||||||||||  prednisone / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Prednisone and ibuprofen conjugate Janus dendrimers and their anticancer activity. (Pubmed Central) -  Apr 1, 2024   
    Also, no cytotoxic effects of dendrons and dendrimers on non-cancerous kidney COS-7 cell line was observed. The interesting anticancer activity of the prepared prednisone-ibuprofen Janus dendrimer conjugates suggest that the dendrimers could be of potential use as new anticancer drug.
  • ||||||||||  Review, Journal:  Effects of major analgesics on male fertility: A systematic literature review. (Pubmed Central) -  Mar 28, 2024   
    The effects of aspirin on male fertility are still unclear due to the lack of studies and consistent methodologies. There is not enough research on dipyrone and its relationship with male fertility, requiring more studies in this area.
  • ||||||||||  ibuprofen / Generic mfg.
    Preclinical, Journal:  Protective Effects of Propolis and Chitosan Nanoparticles against Ibuprofen-Induced Hepatotoxicity in Albino Rats. (Pubmed Central) -  Mar 27, 2024   
    These alterations were improved by propolis and chitosan extracts, which was further confirmed in experimental animals. This study demonstrated that propolis and chitosan nanoparticle extracts have the potential to protect against hepatotoxicity induced by ibuprofen, due to their ability to regulate anti-inflammatory and anti-oxidative defense activities.
  • ||||||||||  5-fluorouracil / Generic mfg., ibuprofen / Generic mfg.
    Journal:  pNIPAm-Based pH and Thermoresponsive Copolymer Hydrogel for Hydrophobic and Hydrophilic Drug Delivery. (Pubmed Central) -  Mar 27, 2024   
    Moreover, the MTT assay and hemocompatibility analysis results proved that the pNIPAm-co-pGMA-Mela hydrogel system is biocompatible and hemocompatible, suggesting that that it could be used for drug delivery applications. The experimental results suggest that the proposed pNIPAm-co-pGMA-Mela hydrogel system is responsive to dual pH and temperature stimuli, and could be a promising drug carrier system for both hydrophilic and hydrophobic drug delivery applications.
  • ||||||||||  Journal:  Non-opioid analgesic combinations following total hip arthroplasty (RECIPE): a randomised, placebo-controlled, blinded, multicentre trial. (Pubmed Central) -  Mar 22, 2024   
    P4
    The photocatalyst showed an excellent reusability performance with a slight decrease after five runs to 93% photodegradation efficiency. In adults undergoing total hip arthroplasty, a combination of paracetamol, ibuprofen, and dexamethasone had the lowest morphine consumption within 24 h following surgery and the most favourable adverse event profile, with a lower incidence of serious and non-serious adverse events (primarily driven by differences in nausea, vomiting, and dizziness) compared with paracetamol plus ibuprofen.
  • ||||||||||  lacosamide / Generic mfg.
    Trial completion:  The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients (clinicaltrials.gov) -  Mar 21, 2024   
    P3,  N=200, Completed, 
    In adults undergoing total hip arthroplasty, a combination of paracetamol, ibuprofen, and dexamethasone had the lowest morphine consumption within 24 h following surgery and the most favourable adverse event profile, with a lower incidence of serious and non-serious adverse events (primarily driven by differences in nausea, vomiting, and dizziness) compared with paracetamol plus ibuprofen. Recruiting --> Completed
  • ||||||||||  methimazole / Generic mfg., propranolol / Generic mfg., ibuprofen / Generic mfg.
    RHABDOMYOLYSIS AS INITIAL PRESENTATION OF GRAVES' DISEASE () -  Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_668;    
    Currently, there have only been 7 reported cases of rhabdomyolysis as a result of thyrotoxicosis. We are reporting the 1st case of such association in the Philippines.